Surgery>>>>>Soft Tissue Sarcomas
Question 2#

Which of the following is NOT associated with the development of sarcoma?

a. Radiation exposure
b. Herbicide exposure
c. Chronic lymphedema
d. History of trauma

Correct Answer is D


External radiation therapy is a rare but well-established risk factor for soft tissue sarcoma that may be associated with radiation-induced mutations of the p53 gene. Exposure to herbicides, such as phenoxyacetic acids and to wood preservatives containing chlorophenols, has been linked to an increased risk of soft tissue sarcoma. In 1948, Stewart and Treves first described the association between chronic lymphedema after axillary dissection and subsequent lymphangiosarcoma. Although patients with sarcoma often report a history of trauma, no causal relationship has been established. More often, a minor injury calls attention to a pre-existing tumor.