Which diseases are associated with germline mutations in the RET tyrosine kinase receptor gene?
A. Multiple endocrine neoplasia type 2A (MEN2A)Mutations in the extracellular domain of the RET tyrosine kinase receptor are associated with multiple endocrine neoplasia type 2A (MEN2A), familial medullary thyroid cancer (FMTC), and Hirschsprung disease. Mutations in the intracellular domain are associated with MEN2B, FMTC, and Hirschsprung disease.