Plastic Surgery>>>>>Burns and trauma
Question 4#

Regarding Integra®, which of the following statements is true?

a. A major drawback in the use in burns reconstruction is that Integra® contracts
b. Integra® is a biodegradable skin regeneration template
c. Integra® contains cross-linked Type I bovine tendon collagen and a shark-derived glycosaminoglycan (chondroitin-4-sulphate)
d. Integra® is microbiologically inert and easily causes infection
e. Integra® is a bilaminar biodegradable tissue engineered dermal matrix generation template

Correct Answer is E

Comment:

Integra® is a bilaminar biodegradable tissue engineered dermal matrix generation template. Integra® does not inherently contract. It is physically inert, but placed in a flexor recipient site without postoperative rehabilitation and the newly generated auto-collagenous dermal matrix will contract. Of note, Integra® contains chondroitin-6-sulphate, does not cause infection but can become infected, and does not act as a template for skin regeneration.

References:
1. Young RC, Burd A. Paediatric upper limb contracture release following burn injury. Burns 2004; 30(7): 723-8.