Which of these is not a predisposing factor to the development of melanoma?a. Giant congenital melanocytic naevus
Pseudoxanthoma elasticum. Pseudoxanthoma elasticum is not a predisposing factor to the development of melanoma. It is a genetic disorder of elastic tissue involving skin, eyes and the cardiovascular system with no malignant potential. All the others can predispose to the development of melanoma. Acquired melanocytic naevi (MN) in Caucasian populations are important markers for the risk of melanoma development. The total number of MN on the whole body is the most important independent risk factor for melanoma and the risk of melanoma development increases almost linearly with rising numbers of MN (the average person has 20-40 acquired naevi).