Urology>>>>>Basic Science and Molecular Oncology
Question 1#

Which of the following is a neoplastic condition in which malignant cells have not invaded across the cellular basement membrane?

a. Metaplasia
b. Adenocarcinoma
c. Atypical small acinar proliferation
d. Carcinoma in situ
e. Perineural invasion

Correct Answer is D


Answer D

Carcinoma in situ (CIS) is a flat, non-invasive neoplastic condition in which the cancerous cells have not invaded through the basement membrane of the cell. The basement membrane of a cell provides structural support and forms a selective barrier between the cell and the surrounding tissue. Once the cancer cells reach beyond the basement membrane, an invasive neoplasia is formed. In most cancers, CIS is pre-malignant; however, in bladder CIS it is considered to be a pre-invasive papillary cancer in which there is a greater than 50% chance of progression into invasive disease.