Which of the following drugs have shown efficacy in the treatment of ‘hot flushes’ following hormonal treatment for advanced prostate cancer?
A. DiethylstilbestrolAnswer C
Medroxyprogesterone 20 mg od has been shown to significantly reduce hot flushes; cyproterone acetate also reduces flushes.
Further Reading:
Irani J et al. Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: A double-blind, randomised trial. Lancet Oncol 2010; 11(2): 147–154.