The following are TRUE for Y microdeletions and infertility except:
A. Y deletions are not found in normospermic manAnswer C
Y deletions (Yq11 micro-deletions) were not found in normospermic men and thus have a clear-cut cause effect relationship with spermatogenic failure. The highest frequency is found in azoospermic men (8%–12%) followed by oligospermic (3%–7%) men. Deletions are extremely rare with a sperm concentration >5 millions of spermatozoa/mL. (approximately 0.7%). The most frequently deleted region is AZFc (approximately 65%–70%), followed by deletions of the AZFb and AZFb+c or AZFa+b+c regions (25%–30%) whereas deletions of the AZFa region are extremely rare (5%). The complete removal of the AZFa and AZFb regions is associated with severe testicular phenotype, Sertoli cell-only syndrome and spermatogenic arrest, respectively. The complete removal of the AZFc region causes a variable phenotype which may range from azoospermia to oligozoospermia. Classical AZF deletions do not confer risk for cryptorchidism or testis cancer.