Urology>>>>>Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS)
Question 3#

The following are true regarding the zonal anatomy of the prostate, EXCEPT:

A. There are four zones (central, transition zone, peripheral zone, anterior fibromuscular septum)
B. BPH mainly affects the peripheral zone
C. The peripheral zone comprises 65% of glandular tissue of the prostate
D. The transition comprises around 10% of the glandular tissue
E. The majority of cancers are located in the peripheral zone

Correct Answer is B


Answer B

There are four zones (central zone, transition zone, peripheral zone and anterior fibromuscular septum). BPH first develops in the periurethral transition zone of the prostate. Nodular hyperplasia is an early phase of the disease, and in the later phase, the size of the nodules increases with the enlargement of glandular nodules. Alpha 1a is the most abundant adrenoreceptor subtype in the prostate. The transition zone comprises 10% of the glandular tissue, whilst the peripheral zone constitutes 65%. The remaining tissue is stroma. Most cancers arise in the peripheral zone.