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Question 19#

The following antibiotics are safe in one or all trimesters of pregnancy, except:

a. Co-amoxiclav
b. Trimethoprim
c. Nitrofurantoin
d. Cefalexin
e. Gentamicin

Correct Answer is E

Comment:

Answer E

Penicillin, cephalosporin and macrolide antibiotics are considered safe to use in pregnancy. Nitrofurantoin is also safe for most of pregnancy but should be avoided towards term due to an increased risk of neonatal haemolysis. Trimethoprim is a folate antagonist and should be avoided, especially in the first trimester during organogenesis. There is a risk of auditory or vestibular nerve damage with gentamicin and therefore should not be used in pregnancy. There is limited information on tazocin or carbapenems with manufactures advising to use only if the potential benefit outweighs the risk in more severe infections.