Cardiology>>>>>Physiology/Biochemistry
Question 1#

At the level of the endothelium, nitric oxide (NO) causes the following except:

a. Promotes smooth muscle relaxation
b. Reduced leukocyte adhesion
c. Increased smooth muscle proliferation
d. Downregulation of oxidative enzymes

Correct Answer is C

Comment:

Increased smooth muscle proliferation. NO has important effects on the endothelium to produce vasodilation, reduced leukocyte adhesion and platelet reactivity, and downregulation of oxidative enzymes. Consistent with these beneficial effects, NO results in a reduction in smooth muscle proliferation, not an increase.