Cardiology>>>>>Physiology/Biochemistry
Question 6#

The final common pathway of platelet aggregation is mediated through

A. Adenosine diphosphate (ADP) binding
B. Collagen
C. Thrombin
D. αvβ3 receptor
E. Glycoprotein (GP) IIb/IIIa receptor

Correct Answer is E

Comment:

Glycoprotein (GP) IIb/IIIa receptor. ADP, collagen, and thrombin bind independently, leading to platelet activation and, ultimately, to expression of the GP IIb/IIIa receptor. GP IIb/IIIa receptor expression leads to platelet clumping by binding to surrounding activated platelets. The αvβ3 receptor does not lead to platelet aggregation.