Which cytokine is anti-inflammatory and increases after shock and trauma?
A. Interleukin (IL)-1Interleukin (IL)-10 is considered an anti-inflammatory cytokine that may have immunosuppressive properties. Its production is increased after shock and trauma, and it has been associated with depressed immune function clinically, as well as an increased susceptibility to infection. IL-10 is secreted by T cells, monocytes, and macrophages, and inhibits proinflammatory cytokine secretion, 02 radical production by phagocytes, adhesion molecule expression, and lymphocyte activation. Administration of IL-10 depresses cytokine production and improves some aspects of immune function in experimental models of shock and sepsis.