The proliferative phase of wound healing occurs how long after the injury?a. 1 day
Normal wound healing follows a predictable pattern that can be divided into overlapping phases defined by the cellular populations and biochemical activities: (1) hemostasis and inflammation, (2) proliferation, and (3) maturation and remodeling. The proliferative phase is the second phase of wound healing and roughly spans days 4 through 12. It is during this phase that tissue continuity is reestablished. Fibroblasts and endothelial cells are the last cell populations to infiltrate the healing wound, and the strongest chemotactic factor for fibroblasts is platelet-derived growth factor (PDGF). Upon entering the wound environment, recruited fibroblasts first need to proliferate, and then become activated, to carry out their primary function of matrix synthesis remodeling. This activation is mediated mainly by the cytokines and growth factors released from wound macrophages.