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Question 5#

Which of the following factors are suggestive of a hereditary cancer? 

A) Tumor development at a younger than normal age
B) Presence of bilateral disease
C) Association with paraneoplastic syndrome
D) Presence of multiple primary malignancies

Correct Answer is C

Comment:

The following factors may suggest the presence of a hereditary cancer:

1. Tumor development at a much younger age than usual.
2. Presence of bilateral disease.
3. Presence of multiple primary malignancies.
4. Presentation of a cancer in the less affected sex ( eg, male breast cancer).
5. Clustering of the same cancer type in relatives.
6. Occurrence of cancer in association with other conditions such as mental retardation or pathognomonic skin lesions.