The most significant side effect of sirolimus is:
A. AnemiaOne of the most significant side effects of sirolimus is hypertriglyceridemia, a condition that may be resistant to statins and fibrates. Impaired wound healing (immediately post-transplant in particular), thrombocytopenia, leukopenia, and anemia also are associated with sirolimus, and these problems are exacrbated when it is used in combination with MMF.