The rare adenocarcinoma of the apocrine gland that often appears as a nonpigmented plaque is:
A. AngiosarcomaThis rare adenocarcinoma of apocrine glands arises in perianal and axillary regions and in genitalia of men and women. Clinical presentation is that of erythematous or nonpigmented plaques with an eczema-like appearance that often persist after failed treatment from other therapies. An important characteristic and one that the surgeon must be acutely aware of is the high incidence of concomitant other malignancies with this cutaneous disease. Forty percent of cases are associated with primary gastrointestinal and genitourinary malignancies, and a diligent search should be made after a diagnosis of extramammary Paget disease is made. Treatment is surgical resection with negative microscopic margins, and adjuvant radiation may provide additional locoregional control.