Surgery>>>>>Breast
Question 18#

Which of the following is true concerning breast cancer during pregnancy? 

A. Metastases to lymph nodes occur in approximately 75% of patients
B. Approximately 50% of breast nodules developing during pregnancy are malignant
C. Mammography is especially useful in localizing small lesions
D. There is risk of chemotherapy teratogenicity if used during the second, but not the third, trimester of pregnancy

Correct Answer is A

Comment:

Breast cancer occurs in 1 of every 3000 pregnant women, and axillary lymph node metastases are present in up to 75% of these women. Fewer than 25% of the breast nodules developing during pregnancy and lactation will be cancerous. Mammography is rarely indicated because of its decreased sensitivity during pregnancy and lactation; however, the fetus can be shielded if mammography is needed. Chemotherapy administered during the first trimester carries a risk of spontaneous abortion and a 12% risk of birth defects. There is no evidence of teratogenicity resulting from administration of chemotherapeutic agents in the second and third trimesters.