Multiple Choice Questions (MCQ)

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Category: Urology--->Basic Science and Molecular Oncology
Page: 2

Question 6#Print Question

The loss of function of the VHL protein in renal cell carcinoma is mediated by which of the following? 

a. Bcl-2
b. Hypoxia-inducible factor alpha
c. Fibroblast growth factor-3
d. Transforming growth factor beta-1
e. Vascular endothelial growth factor

Question 7#Print Question

Which of the following is the CORRECT sequence of steps in a classical haematological metastatic process?

a. Growth, Extravasation & Migration, Arrest, Survival, Intravasation
b. Extravasation & Migration, Arrest, Survival, Intravasation, Growth
c. Intravasation, Arrest, Extravasation & Migration, Survival, Growth
d. Intravasation, Arrest, Survival, Extravasation & Migration, Growth
e. Extravasation & Migration, Arrest, Growth, Survival, Intravasation

Question 8#Print Question

Regarding the following table, which of the following is FALSE?

a. Sensitivity = w/(w + y)
b. Specificity = z/(x + z)
c. Positive predictive value (of positive test) = w/(w + x)
d. Negative predictive value (of negative test) = y/(x + z)
e. The screen positive rate can be calculated from the table

Question 9#Print Question

Regarding the major histocompatability complex (MHC), which of following is FALSE?

a. MHC Class I molecules are associated with a light chain, beta-2 microglobulin
b. T lymphocytes are unable to recognise antigens bound to the MHC molecules
c. MHC is involved in recognising and binding to foreign antigens
d. MHC Class II molecules are composed of two heavy chains each with two domains
e. MHC Class III proteins include cytokines

Question 10#Print Question

Which of the following immunohistochemical features would be associated with an aggressive tumour in bladder cancer?

a. Low p53
b. High E-cadherin
c. High Ki67
d. Low Rb
e. None of the above

Category: Urology--->Basic Science and Molecular Oncology
Page: 2 of 2