Multiple Choice Questions (MCQ)

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Category: Psychiatry--->Pharmacology
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Question 1# Print Question

On administration of an unknown dose of a new antipsychotic, a 55-yearold man develops extra pyramidal symptoms.

The dose at which this effect appears would be established in which phase of clinical trials?

A. Phase 1
B. Phase 2
C. Preclinical phase
D. Phase 3
E. Phase 4

Question 2# Print Question

Haloperidol is more potent than chlorpromazine. Potency of a therapeutic formulation refers to:

A. Strength of binding to receptors
B. Duration of action at receptors
C. Size of the dose required to produce an effect
D. Elimination half-life of a drug
E. Proportion of available receptors occupied by a drug

Question 3# Print Question

Absorption of orally administered drugs is affected by which of the following:

A. Intestinal transit
B. Co-administered drugs
C. P-glycoprotein
D. Presence of food
E. All of the above

Question 4# Print Question

Which of the following conditions predisposes to a higher rate of transport through the blood–brain barrier?

A. Presence of ionized drug molecules
B. Presence of protein-bound drug molecules
C. Presence of water-soluble drug molecules
D. Presence of inflamed meninges
E. All of the above

Question 5# Print Question

A 72-year-old patient with bipolar illness experiences more side-effects when taking the same medication that he was prescribed 30 years ago, when he was 42 years old.

Which of the following is a possible explanation?

A. Reduced proportion of body fat
B. Increased liver enzyme activity
C. Increased renal clearance of drugs
D. Increased protein-binding fraction
E. All of the above

Category: Psychiatry--->Pharmacology
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