Multiple Choice Questions (MCQ)

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Category: Surgery--->Wound Healing
Page: 1

Question 1# Print Question

Which of the following is FALSE regarding polymorphonuclear neutrophils (PMNs) and their role in wound healing?

A. PMNs release proteases that degrade ground substance within the wound site
B. Neutrophils use fibrin clot generated at the wound site as scaffolding for migration into the wound
C. Neutrophil migration is stimulated by local prostaglandins, complement factors, interleukin- 1 (IL- l ) , tumor necrosis factor-α (TNF-α), transforming growth factor- β (TGF- β), platelet factor 4, or bacterial products
D. PMNs are the first cells to infiltrate the wound, peaking at 24 to 48 hours
E. Neutrophils release cytokines that later assist with collagen deposition and epithelial closure

Question 2# Print Question

The proliferative phase of wound healing occurs how long after the injury? 

A. 1 day
B. 2 days
C. 7 days
D. 14 days

Question 3# Print Question

Which of the following is true regarding the fibroblastic phase of wound healing?

A. Early during wound healing, the predominant composition of the matrix is fibronectin and type II collagen
B. After complete replacement of the scar with type III collagen, the mechanical strength will equal that of uninjured tissue approximately 6 to 12 months postinjury
C. Even though the tensile strength of a wound reaches a plateau after several weeks, the tensile strength will increase over another 6 to 12 months due to fibril formation and cross-linking
D. As the scar matures, matrix metalloproteinases (MMPs) break down type I collagen and replace it with type III collagen

Question 4# Print Question

Which of the following is commonly seen in Ehlers-Danlos syndrome (EDS)?

A. Small bowel obstructions
B. Spontaneous thrombosis
C. Direct or recurrent hernias in children
D. Abnormal scarring of the hands with contractures

Question 5# Print Question

Patients with Marfan syndrome are associated with what genetic defect?

A. MFN-1 gene deletion
B. Type I collagen gene mutation
C. COL7 A 1 gene mutation
D. FBN-1 gene mutation

Category: Surgery--->Wound Healing
Page: 1 of 4