Which one of the following features is least likely to be seen in a patient with pellagra?
Correct Answer C: Depression is quite a common early finding in patients with pellagra.
Pellagra: Pellagra is a caused by nicotinic acid (niacin) deficiency. The classical features are the 3 D's - dermatitis, diarrhoea and dementia.
Pellagra may occur as a consequence of isoniazid therapy (isoniazid inhibits the conversion of tryptophan to niacin) and it is more common in alcoholics.
Features:
Which of the following conditions is inherited in an autosomal recessive fashion?
Correct Answer E: Autosomal recessive conditions are 'metabolic' - exceptions: inherited ataxias Autosomal dominant conditions are 'structural' - exceptions: hyperlipidaemia type II, hypokalaemic periodic paralysis.
Autosomal recessive conditions: Autosomal recessive conditions are often thought to be 'metabolic' as opposed to autosomal dominant conditions being 'structural', notable exceptions:
The following conditions are autosomal recessive:
*this is still a matter of debate and many textbooks will list Gilbert's as autosomal dominant.
Southern blotting is used to:
Correct Answer B:
Molecular biology techniques:
The following table shows a very basic summary of molecular biology techniques:
Which of the following is not a tumour suppressor gene?
Correct Answer E: myc is an oncogene which encodes a transcription factor.
Tumour suppressor genes:
Basics:
Examples:
A 23-year-old student is investigated following an anaphylactic reaction suspected to be secondary to a wasp sting.
Which one of the following is the most appropriate first-line test to investigate the cause of the reaction?
Correct Answer B: Given the history of anaphylaxis it would not be appropriate to perform a skin prick test.
Allergy tests:
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