Who introduced the term ‘second set phenomenon’?
Gibson. Tom Gibson of Glasgow worked on large numbers of burn victims from WWII and observed that although homografts survived for around 2 weeks, if the same donor was used a second time they were rejected immediately. This led to the seminal work carried out with Medawar from Oxford, which formed the basis for the immune response.
Who shared the Nobel Prize for medicine in 1960?
Medawar. In 1942, Peter Medawar from Oxford worked with Tom Gibson at the Glasgow Royal Infirmary where large numbers of burn victims from WWII were treated with skin grafts. His work on the immune response to ‘none-self’ transplants led to the Nobel Prize shared with MacFarlane Burnett in 1960.
Whose graft was called a ‘four-penny graft’?
Lawson. George Lawson (1831-1903) reported his experience with full thickness grafts to the Clinical Society of London in 1871 (a year after Reverdin’s pinch grafts). They were about the size of a four-penny piece. He served as a surgeon in the Crimea where he survived severe illness. On his return, he specialised in ophthalmic surgery.
Apart from devising their eponymous skin grafts what do Lawson and Wolfe have in common?
They were ophthalmologists. They both worked as military surgeons in different campaigns, but they shared the specialty of ophthalmology.
Whose work overcame the difficulties seen with full thickness grafts and very thin grafts that led to the term split skin graft?
Blair and Barret-Brown. Vilray Papin Blair and James Barret-Brown from the Department of Medicine at Washington University reported on the use of large split skin grafts of intermediate thickness in 1929.
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