Multiple Choice Questions (MCQ)

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Category: Psychiatry--->Basic Statistics
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Question 1# Print Question

A study is evaluating the effect of agomelatine on postnatal depression at a mother and baby unit.

Which one of the following should be considered when assessing the internal validity of this study?

A. Benefi ts of agomelatine in major depression outside the postpartum period
B. The degree to which the subjects adhered to the study protocol
C. The cost of using agomelatine compared with standard care
D. Consistency of the reported outcome in comparison with previous studies
E. Benefits of agomelatine in postpartum depression when used at an outpatient service

Question 2# Print Question

A new clinician-administered test for assessing suicidal risk is studied in a prison population in Canada, where a high suicide rate of 1 in 25 has been recorded.

Which of the following indicate that this test is NOT suitable for your clinical population?

A. The positive predictive value is 80%
B. The likelihood ratio for a positive test is 14
C. The prevalence of suicide in your clinical sample is 1 in 890
D. The inter-rater reliability (kappa) of the test is 0.8
E. The literacy rate of the prison population is very low but comparable with your clinical sample

Question 3# Print Question

A new rating scale being evaluated for anxiety has a sensitivity of 80% and specificity of 90% against the standard ICD-10 diagnosis.

The likelihood ratio of a positive result is:

A. Nearly 2
B. Nearly 0.2
C. 0.08
D. 8
E. 0.5

Question 4# Print Question

A pharmaceutical company developed a new antidepressant ‘X’. They conducted a randomized double-blind placebo controlled trial of the drug. The study had two arms: an active medication arm and a placebo arm. Each arm had 100 subjects. Over a 4-week period, a 50% drop in Hamilton depression scale (HAMD) scores were seen in 40 subjects in the active medication arm, while a similar drop was seen only in 20 subjects in the placebo arm.

What is the number needed to treat (NNT) from this trial for the new antidepressant?

A. 1
B. 2
C. 3
D. 4
E. 5

Question 5# Print Question

During the same placebo controlled trial described in question 4, 20% of people on X developed active suicidal ideas, while only 10% of patients on placebo developed the same side-effect.

What is the number needed to harm (NNH) associated with the suicidal ideas from the trial data?

A. 5
B. 10
C. 15
D. 20
E. 25

Category: Psychiatry--->Basic Statistics
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